Human Sera
Cayman Chemical Capsacn 100mg
A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production, as well as reduces LPS- and IFN-induced NO release in isolated mouse peritoneal macrophages at 10 and 50 µM; induces substance P release in rat spinal cord slices (EC50 = 2.3 µM); reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.)
Cayman Chemical 1AmIno1deoxyDfructoseh 100mg
An amino monosaccharide; induces site-specific DNA damage at pyrimidine residues in cell-free assays; 1-amino-1-deoxy-D-fructose moieties have been found as a component of fructosamines
Cayman Chemical PIcrocrocIn 50mg
A monoterpene glycoside with anticancer activity; a biosynthetic precursor of safranal; inhibits the growth of HeLa cells (IC50 = 3 mM)
Cayman Chemical PIzotIfenmalate 100mg
A triptan with high affinity for serotonin and dopamine receptors (Kis = 7.94 and 2.4 nM for 5-HT2C and D2, respectively)
Cayman Chemical Telmsartn 50mg
A nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM); a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM); potently reduces blood pressure
Cayman Chemical D-OrnIthIn lactam 50mg
A building block; has been used in the synthesis of HCV NS5B inhibitors, as well as αVβ3 integrin receptor antagonists
Cayman Chemical PIperoxnhydrochlorIde 100mg
An α2-AR antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively); reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats at 10 mg/kg
Cayman Chemical TopIroxostat 100mg
An inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM); inhibits ABCG2 in isolated human plasma (IC50 = 0.18 µM); increases LPS-induced decreases in Bcl-2 levels and decreases LPS-induced increases of Bax and cleaved caspase-3 levels in H9c2 rat cardiomyocytes at 5 µM; chronic administration results in the presence of urinary xanthine crystals and induces nephropathy in rats at 0.2 and 1 mg/kg, respectively
Cayman Chemical 8-HydroxygunInhydrochlorI 50mg
A polyamine with diverse biological activities scavenges DPPH superoxide and hydroxyl radicals in cell-free assays (IC50s 38.5 291.6 and 351.9 UM respectively) inhibits tyrosinase (IC50 291.3 UM for the mushroom enzyme) and forskolin-induced pigmentation in B16/F10 cells at 50 UG/ml inhibits LPS-induced increases in NO and iNOS levels as well as NF-KB activity in RAW 264.7 macrophages at 50 UM
Cayman Chemical LLysIn lactamhydrochLRId 50mg
A building block; has been used in the synthesis of HIV protease inhibitors, as well as bengamide derivatives with in vitro anticancer activity
Cayman Chemical 2ImIno4methylpIperIdIna 50mg
2-Imino-4-methylpiperidine is a potent, general NOS inhibitor. It exhibits IC50 values of 0.1, 1.1, and 0.2 µM for inhibition of human iNOS, eNOS, and nNOS, respectively, at an arginine concentration of 30 µM.{5579}
Cayman Chemical DIhydrodaIdzeIn 50mg
An active, estrogenic metabolite of daidzein; has vasodilatory action on rat isolated aortic rings at 1 UG/ml; stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations
Cayman Chemical Linolenic ACD 50mg
γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Cayman Chemical Metanephrine 50mg
An inactive metabolite of epinephrine; urinary and plasma levels are increased in patients with pheochromocytoma
Cayman Chemical aPropylamInopentIophenonh 50mg
A substituted cathinone that has propyl groups both at the α position of the cathinone structure and at the amine